The Defense Advanced Research Projects Agency (DARPA), the U.S. Defense Department’s high-risk granting body, is about to jump into synthetic biology in a big way. One of the latest research buzzwords, synthetic biology means different things to many. But for a new DARPA program, it represents modifying the metabolic and genetic machinery of cells to produce useful products. “We want to create a new manufacturing capability for the United States,” says DARPA Program Manager Alicia Jackson. Approved barely a month ago, the $30 million Living Foundries program should be sending out a request for proposals in the next few weeks and making awards several months from now.